Iquitos is widely considered the largest continental city unreachable by road. That leaves planes and boats as the primary means of entrance and egress for both people and supplies.

Do not expect to see a city with all the trappings of the western world. This city is very basic as it has no road connection with the rest of the world. Vehicles are old and most vehicles on the meager roads are "motor taxis" or three wheeler motorbikes which can carry three at a pinch. The people are friendly once you get past the taxi drivers at the airport. Getting to Iquitos, located deep in the heart of the Peruvian Amazon, is an adventure in itself due to its remote location. Here's how to reach this unique city:
By Air: The most common way to reach Iquitos is by air. Iquitos is serviced by Coronel FAP Francisco Secada Vignetta International Airport (IQT). You can catch a flight to Iquitos from Lima, the capital of Peru, as well as some other major cities in the country. Several airlines operate regular flights to Iquitos.
By River: Iquitos is a major port on the Amazon River, and river travel is an integral part of the region's transportation network. You can take a slow boat or a faster speedboat from other Amazonian towns and cities, such as Pucallpa and Yurimaguas. Keep in mind that river travel can be lengthy, with journeys taking several days or more, but it provides a unique opportunity to witness the Amazon's diverse ecosystems.
By Road and River: Some travelers choose to combine road and river travel. They might take a bus from Tarapoto to Yurimaguas and then continue by boat to Iquitos.
It's essential to plan your journey in advance, considering factors like weather conditions, transportation schedules, and the duration of your trip. The remote nature of Iquitos makes it a truly unique destination, and the journey to get there is an integral part of the adventure.